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KMID : 0381319900290020056
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Korean Journal of Occupational Health
1990 Volume.29 No. 2 p.56 ~ p.65
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Urinary Excretion of Hippuric Acid and Subjective Symptoms Among Workers Occupationally Exposed to Toluene
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Abstract
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To investigate the relationship of subjective symptoms of toluene exposed workers with their urinary excretion of hippuric acid as an index of biological monitoring of toluene, 335 toluene exposed workers were studied.
Selected study variables were urinary concentration of hippuric acid, subjective symptoms of each workers relevant to toluene exposure, air concentration of toluene of workplace, hemoglobin, hematocrit, red & white blood cells count and basic liver function test (SGOT & SGPT).
The results obtained were as follows
1. The mean air concentration of toluene were 24 ppm in A company and 118 ppm in B company.
2. There was no differences in hematologic and liver function test between A & B company.
3. Prevalence rates of subjective symptoms were significantly higher in B company than A company. Dimmed vision was the highest complained symptom during work. Unusual smell and irritation of eyes were second and third in order. During the past 6 months, strained eye, muddle-headness and fatigue were most frequent symptoms out of 55 symptom questions.
4. There was significant correlation between urinary hippuric acid and prevalence rate of subjective symptoms.
5. Workers whose work duration were longer than 8 years showed lowest prevalence rate of subjective symptoms and there was no dose-response relationship between prevalence rate of subjective symptoms and work duration of workers.
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